Nicotinamide Adenine Dinucleotide (NADH)

Overview Originally discovered in 1905 in yeast, NADH is also known as the reduced form of coenzyme 1, a complementary enzyme utilized in the production and regulation of energy (oxidative phosphorylation). A coenzyme is the active or working form of a vitamin. NADH is the reduced (electron-energy rich) coenzyme form of vitamin B3; while NAD is the oxidized (burned) coenzyme form of vitamin B3. NAD and NADH are converted into each other in numerous different metabolic activities. In some metabolic reactions, it is NAD which is the needed catalyst, with NADH a useful by-product; in other reactions the situation is reversed. NAD and NADH also serve to activate various enzymes. NADH is the first of five enzyme complexes of the electron transport chain where much of the ATP bioenergy that runs every biological process of the body is formed. NADH is necessary to oxidize all foodstuffs (fats, sugars, amino acids) into ATP bioenergy. As all living cells require energy to survive, NADH reacts with oxygen to form water and energy. One molecule of NADH yields three molecules of ATP (the stored form of energy), with the amount of NADH present dictating the amount of energy produced. The heart muscle cells contain … Continue reading Nicotinamide Adenine Dinucleotide (NADH)